5-Aminosalicylate Induced Nephrotoxicity

Introduction

In the absence of a diagnostic test for 5-ASA induced nephrotoxicity, definitions are below.

For study inclusion participants must meet all the major criteria and any number of the additional 4 minor criteria. The presence or absence of other risk factors for renal disease distinguishes category B from category A patients. Patients will be classified A0-4 or B0-4 depending upon the number of minor criteria met. Thus a diagnosis of 5-ASA induced nephrotoxicity will be most confident in patients designated A4 and least confident in those designated B0.

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